New Frontiers in Gene Targeting.

New frontiers in transfusion medicine: gene therapy

Techniques of separation, purification as well as cryopreservation of marrow, blood, cord blood or tissue cells have been developed in blood banks. Transfusion medicine, over the last 20 years, has advanced radically from total blood transfusion to cell and ex vivo gene therapy, going through different stages, including the production of well-defined cell products (red blood cells, platelets, g...

New Frontiers in Cancer Chemotherapy — Targeting Cell Death Pathways

Cell death plays an important role in tumorigenesis, growth, and progression and affects the efficiency of chemotherapy to a great extent. Apoptosis is usually regarded as the principal mechanism of chemotherapy-induced cell death. However, the dysregulation of apoptosis occurs commonly in many cancers, which lowers the effectiveness of therapy and allows cells to survive. The mechanisms by whi...

NEW FRONTIERS IN ANGIOGENESIS New Frontiers in Angiogenesis

New frontiers in arrhythmias.

Understanding of the mechanisms responsible for disorders of cardiac rhythm has been increasing rapidly in the past I0 years. A great stimulus to these advances in knowledge has been the recognition in Coronary Care Units of the high mortality associated with some arrhythmias. The principal inroads that have been made into the high mortality of patients with acute myocardial infarction who are ...

New Frontiers in Applied Probability

Suppose that N is a Z+-valued random variable and that X,X1, X2, . . . is a sequence of independent and identically distributed Z+ random variables independent of N . In this paper we are interested in properties of the conditional variable Nk D =(N | ∑Nj=1 Xj = k). In particular, we want to know the asymptotic behavior of the conditional mean ENk or the conditional variance var Nk as k → ∞. We...